Pre- and Perinatal Ischemia-Hypoxia, the Ischemia-Hypoxia Response Pathway, and ADHD Risk
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چکیده
منابع مشابه
Hypoxia and Ischemia
The mechanisms underlying the marked increase in [K']. in response to ischemia are not fully understood. Accordingly, the present study was performed to assess the contribution of ATP-regulated K' channels by using simultaneous measurements of cellular K+ efflux, [K'],, transmembrane action potentials, and tissue ATP, ADP, phosphocreatine, and creatine content in a unique isolated, bloodperfuse...
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1 RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany, 2 RG Neuroand Sensory Physiology, Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany, 3 RG Neurovascular Research, Institute of Physiology and Pathophysiology, University...
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Perinatal hypoxia/ischemia (H/I) is the leading cause of neurologic injury resulting from birth complications. Recent advances in critical care have dramatically improved the survival rate of infants suffering this insult, but approximately 50% of survivors will develop neurologic sequelae such as cerebral palsy, epilepsy or cognitive deficits. Here we demonstrate that tripotential neural stem/...
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Neonatal hypoxic ischemic encephalopathy (HIE) is a common health problem and occurs in approximately 16 in 1000 term infants every year. After the initial hypoxic ischemic insult, brain injury evolves for days and possibly even weeks. The severity of the injury depends on the gestational age and duration of the insult. The exact underlying mechanisms of neonatal HIE remain undefined and many d...
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Retinal hypoxia is the potentially blinding mechanism underlying a number of sight-threatening disorders including central retinal artery occlusion, ischemic central retinal vein thrombosis, complications of diabetic eye disease and some types of glaucoma. Hypoxia is implicated in loss of retinal ganglion cells (RGCs) occurring in such conditions. RGC death occurs by apoptosis or necrosis. Hypo...
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ژورنال
عنوان ژورنال: Behavior Genetics
سال: 2016
ISSN: 0001-8244,1573-3297
DOI: 10.1007/s10519-016-9784-4